目的探讨血清细胞因子水平与妊娠期糖尿病(GDM)的相关性及其临床意义。方法选择54例GDM患者作为研究对象,选择同期体检的健康妊娠妇女60例作为对照组,ELISA法检测血清肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)水平,同时采用稳态模型评估法(HOMA)评估胰岛素抵抗指数(HOMA-IR)。结果与对照组比较,GDM组患者血清TNF-α[(82.53±21.85)pg/ml vs(45.27±12.53)pg/ml]、IL-6水平[(98.43±28.73)pg/ml vs(59.34±17.28)pg/ml]和HOMA-IR[(2.13±0.69)vs(1.36±0.32)]均明显增高,差异有统计学意义(P均<0.01);GDM患者血清TNF-α和IL-6与HOMA-IR分别呈正相关(r=0.784,0.725),差异有统计学意义(P均<0.05)。结论 GDM患者血清细胞因子TNF-α和IL-6水平明显增高,与GDM发生密切相关。 Objective To investigate the correlation between serum cytokine levels and gestational diabetes mellitus (GDM) and its clinical significance. Methods Fifty-four patients with GDM were selected as study subjects. Sixty healthy pregnant women were selected as the control group during the same period. Serum levels of TNF-α and IL-6 were measured by ELISA. At the same time, HOMA was used to assess the insulin resistance index (HOMA-IR). Results Compared with the control group, the levels of serum TNF-α [(82.53 ± 21.85) pg / ml vs (45.27 ± 12.53) pg / ml] and IL-6 levels in the GDM group [(98.43 ± 28.73) pg / ml vs 17.28) pg / ml] and HOMA-IR [(2.13 ± 0.69) vs (1.36 ± 0.32) vs (1.36 ± 0.32)], all of which were significantly different HOMA-IR were positively correlated (r = 0.784,0.725), the difference was statistically significant (P all <0.05). Conclusion Serum levels of TNF-α and IL-6 in patients with GDM are significantly increased, which are closely related to the occurrence of GDM.