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[Objective] Based on oxidative stress and inflammatory mechanism,the protective effects of Qiweijingganling(QWJGL) on rats liver injury induced by alcohol were researched,which contained seven Traditional Chinese Medicines.[Methods]A total of 72 rats were randomly divided into six groups according to the body weight,which were normal group,model group,bifendate group(50 mg/kg) and QWJGL dosage groups(400,200,100 mg/kg).Administration was carried out once each day.On the 30 thday,rats were given 53% white wine(0.1kg/d) by gavage,except the normal group.The alcoholic liver damage model was established.Effects on alanine aminotransferase(ALT),glutamic oxalacetic transaminase(AST),malondialdehyde( MDA),glutathione peroxidase(PSH-PX) and superoxide dismutase(SOD) activity were detected by colorimetry.Liver tissue tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) contents were detected by ELISA method.[Results] Compared with model group,QWJGL significantly reduced the ALT,AST and MDA actives in rats serum,enhanced the PSH-PX and SOD activities,and lowered the TNF-α and IL-6 contents in liver tissues( P < 0.05).[Conclusions]QWJGL reduced the rats liver injury induced by alcohol,the mechanism of which might be related to the reduction of oxidative stress and anti-inflammatory action.