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目的:观察复方丹参滴丸对冠心病患者血清C反应蛋白(CRP)及胞间粘附分子1(ICAM-1)水平的影响。方法:将84例冠心病患者随机分为观察组及对照组各42例,对照组患者给予美托洛尔治疗,12.5~25 mg/次,2次/d,观察组在对照组基础上给予复方丹参滴丸治疗,10粒/次,3次/d,4周为1疗程,持续治疗6个月。分别于治疗前后统计两组患者心绞痛发作频率持续时间及硝酸甘油用量,应用无创血流动力学检测仪监测患者血流动力学指标,应用放射免疫法测定两组患者血清CRP,应用ELISA法测定两组患者血清ICAM-1。结果:观察组总有效率为95.24%,对照组总有效率为76.19%,差异有统计学意义(P<0.05)。观察组治疗后心绞痛发作频率、持续时间及硝酸甘油用量显著少于对照组(P<0.05)。观察组治疗后纤维蛋白原(Fb)、血沉值(ESR)、低切变率下全血黏度(nbl)、高切变率下全血黏度(nbh)水平显著低于对照组(P<0.05)。观察组治疗后血清CRP及ICAM-1水平显著低于对照组(P<0.05)。结论:复方丹参滴丸能有效提高冠心病患者疗效,改善患者血流动力学指标,降低患者血清CRP及ICAM-1水平。
Objective: To observe the effect of Fufang Danshen Diwan on the levels of serum C-reactive protein (CRP) and intercellular adhesion molecule-1 (ICAM-1) in patients with coronary heart disease. Methods: Eighty-four patients with coronary heart disease were randomly divided into observation group and control group, 42 cases in each group. Patients in the control group were treated with Metoprolol, 12.5-25 mg / time, twice a day. The observation group was given on the basis of the control group Compound Danshen dripping pills treatment, 10 capsules / time, 3 times / d, 4 weeks for a course of treatment, continuous treatment for 6 months. The duration of angina pectoris episodes and the dosage of nitroglycerin in both groups were measured before and after treatment. The hemodynamic parameters of the two groups were measured by non-invasive hemodynamic analyzer. The serum CRP levels were measured by radioimmunoassay. The serum levels of CRP Group patient serum ICAM-1. Results: The total effective rate was 95.24% in the observation group and 76.19% in the control group, the difference was statistically significant (P <0.05). After treatment, angina pectoris frequency, duration and dosage of nitroglycerin in observation group were significantly less than those in control group (P <0.05). Fb, ESR, nbl and nbh in the observation group were significantly lower than those in the control group (P <0.05) ). The levels of serum CRP and ICAM-1 in the observation group were significantly lower than those in the control group (P <0.05). Conclusion: Compound Danshen Dripping Pills can effectively improve the curative effect of patients with coronary heart disease, improve hemodynamics and decrease the level of serum CRP and ICAM-1 in patients.