血清PTX3、KIM-1和Hcy联合检测在糖尿病肾病患者诊断中的临床价值

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目的 研究血清五聚素3(PTX3)、肾损伤分子1(KIM-1)、同型半胱氨酸(Hcy)联合检测在糖尿病肾病(DN)患者诊断中的临床价值.方法 选取2015年3月至2019年6月于攀枝花市仁和区人民医院收治的92例DN患者作为DN组,另选30例体检正常者作为正常组,比较两组及不同病情程度、病情分期DN患者的PTX3、KIM-1、Hcy水平,利用ROC曲线分析PTX3、KIM-1、Hcy及联合检测对DN患者的诊断价值.结果 DN组的血清PTX3、KIM-1、Hcy水平均高于正常组(P<0.05);中晚期组的血清PTX3、KIM-1、Hcy水平均高于早期组(P<0.05);重度组的血清PTX3、KIM-1、Hcy水平均高于轻度组(P<0.05);血清PTX3、KIM-1、Hcy联合诊断DN的曲线下面积(AUC)为0.880(95%CI:0.814-0.946),且联合诊断的AUC高于单一诊断(P<0.05).结论 血清PTX3、KIM-1、Hcy联合检测可有效诊断DN,同时较好地对DN分期、分级,对于临床DN治疗具有重要意义.
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