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目的:通过应用宫保散联合宫颈环形电切术(LEEP)治疗宫颈癌前病变并发高危型人乳头瘤病毒(HPV)感染,观察其临床疗效及预后,为临床治疗提供依据。方法:选择太和县人民医院2013年7月~2014年6月宫颈癌前病变并发HPV感染患者92例,随机分为对照组和观察组,每组46例,对照组应用LEEP治疗,观察组应用宫保散联合LEEP治疗。观察手术情况、治疗效果、HPV病毒载量并评估生活质量。结果:两组出血量和手术时间比较,差异无统计学意义(P>0.05);观察组治愈为91.30%(42/46),高于对照组[82.61%(38/46)],两组比较,差异有统计学意义(P<0.05);观察组生活质量评分为(87.96±3.11)分,对照组为(81.34±2.75)分,两组比较,差异有统计学意义(P<0.05);观察组治疗后HPV病毒载量为(1.18±0.19)×106copies/ml,低于对照组[(1.65±0.22)×106copies/ml],且两组治疗后均低于治疗前(P<0.05)。观察组治疗后CINⅢ级低于治疗前(P<0.05);观察组治疗后CIN0级高于对照组治疗后(P<0.05);观察组治疗后CINⅠ级Ⅱ级均低于对照组治疗后(P<0.05)。结论:宫保散联合LEEP治疗宫颈癌前病变并发HPV感染具有较好的临床疗效,降低HPV病毒载量,提高患者生活质量。
Objective: To observe the clinical efficacy and prognosis of cervical precancerous lesion complicated with high-risk human papillomavirus (HPV) infection by applying Gongpaisan combined with cervical ring electrosurgical excision (LEEP) to provide the basis for clinical treatment. Methods: 92 patients with cervical precancerous lesions complicated with HPV infection from July 2013 to June 2014 in Taihe People’s Hospital were randomly divided into control group and observation group, with 46 cases in each group. The control group was treated with LEEP, and the observation group Gong Gong scattered LEEP treatment. Observed the operation, treatment effect, HPV viral load and assess the quality of life. Results: There was no significant difference between the two groups in the amount of bleeding and the operation time (P> 0.05). The cure rate in the observation group was 91.30% (42/46), higher than that in the control group (82.61%, 38/46) (P <0.05). The quality of life score of the observation group was (87.96 ± 3.11) points and that of the control group (81.34 ± 2.75) points, the difference was statistically significant (P <0.05), the difference was statistically significant (1.18 ± 0.19) × 106copies / ml in the observation group after treatment, which was lower than that in the control group [(1.65 ± 0.22) × 106copies / ml] ). CIN level in observation group was lower than that before treatment (P <0.05); CIN0 level in observation group was higher than that in control group after treatment (P <0.05); CINⅠ-Ⅱ level in observation group was lower than that in control group after treatment P <0.05). Conclusion: Gongbao Powder combined with LEEP treatment of cervical precancerous lesions complicated with HPV infection has a good clinical efficacy, reduce HPV viral load, improve patient quality of life.