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Using turbidimetry and electronmicroscopy,we examined the effects oftetrandrine (Tet) on the aggregation and morphological changes of rabbit platelets.It wasfound that Tet could markedly inhibit the platelet aggregation induced by ADP,collagenand arachidonic acid (AA) in a dose-dependent manner.The IC_(50) (50% inhibitoryconcentration) was 38.9,30.3 and 44.3μg/ml respectively.The platelets pretreated with Tetcould not be activated by collagen,their morphological changes and granule release didn’toccur and their normal structure was well preserved.In addition,dipyridamole couldenhance the inhibition of Tet on platelet aggregation,while increased extracellular calciumcould weaken this inhibition.
Using turbidimetry and electronmicroscopy, we examined the effects of tetrandrine (Tet) on the aggregation and morphological changes of rabbit platelets. It was found that inhibit the platelet aggregation induced by ADP, collagen and arachidonic acid (AA) in a dose-dependent manner. The IC 50 (50% inhibition of concentration) was 38.9, 30.3 and 44.3 μg / ml respectively. The platelets pretreated with Tetcould not be activated by collagen, their morphological changes and granule release did not toccur and their normal structure was well preserved. addition, dipyridamole couldenhance the inhibition of Tet on platelet aggregation, while increased extracellular calcium can weaken this inhibition.