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综述了肝郁动物模型的复制方法:药物造模法和情志刺激造模法及药物+情志刺激进模法;概述了肝郁动物模型的病理改变,包括循环系统、消化系统、免疫系统及神经内分泌系统的病理改变。评析了肝郁动物模型研究存在的问题。认为建立符合中医肝失疏泄病理特点的慢性心理应激肝郁模型及肝郁模型评价标准,对动物模型病理改变进行多系统、多病种、多指标及多证型之间的比较观察,将是今后的努力方向。
The methods of replicating liver depression in animal models were summarized: drug modeling and emotional stimulation modeling and drug + emotional stimulation modeling; and the pathological changes of liver depression animal model were summarized, including circulatory system, digestive system, immune system And neuroendocrine system pathological changes. The problems existing in the study of animal model of liver depression were analyzed. It is considered that the establishment of chronic liver failure model and liver depression model which meet the characteristics of pathological changes of liver failure and defecation in Chinese medicine should be evaluated. The systematic observation of multiple pathological changes, multiple diseases and multiple syndromes, Will be the direction of future efforts.