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目的检测四环素类似物的体外抗菌活性,以观察类似物的抗菌和趋骨活性的相关性。方法采用纸片琼脂扩散法及试管二倍稀释法。结果四环素类似物的抗菌活性较四环素大幅降低或完全消失。结论通过对四环素的结构简化,保留其趋骨活性而使抗菌作用减弱或消失。
Objective To test the antibacterial activity of tetracycline analogues in vitro and to observe the correlation between the antibacterial activity and the activity of bone-attracting compounds. Methods Paper agar diffusion method and tube double dilution method. Results The antibacterial activity of tetracycline analogs significantly decreased or disappeared completely compared with that of tetracycline. Conclusions The antibacterial effect is weakened or disappeared by simplifying the structure of tetracycline and preserving the activity of its bone-attracting bone.