论文部分内容阅读
近年来,随着循证医学的发展,在临床实践中,越来越需要有证据支持的药物来对患者进行治疗。因此,评价何种抗癫痈药物具有长期效能和效果的最佳证据,就显得非常重要。本文根据 Tracy Glauser 为首的工作组制定的治疗指南,摘取主要内容,对目前有循证依据的抗癫痈药物进行了总结和评价。但我们也需要注意在该指南中没有涉及或者推荐等级不高的药物,并非没有,临床疗效,原因包括:(1)某些药物已经具有了长期临床实践的公认疗效,如果将其再进行对照研究,意义不大;(2)某些药物受到临床试验数量和质量的限制,从而导致对其评价的降低。
In recent years, with the development of evidence-based medicine, there is an increasing need for evidence-based medicine to treat patients in clinical practice. Therefore, it is very important to evaluate which anti-epileptic drugs have the best evidence of long-term efficacy and effectiveness. Based on the treatment guidelines developed by Tracy Glauser’s working group, this paper extracts the main content and summarizes and evaluates the current evidence-based antiepileptic drugs. However, we also need to pay attention to the fact that some of the drugs that have not been involved or recommended in this guideline are not high-grade drugs, but not without clinical efficacy. The reasons include: (1) Some drugs already have the recognized efficacy in long-term clinical practice, Research, of little significance; (2) some drugs are limited by the quantity and quality of clinical trials, resulting in a decrease of its evaluation.