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研究头孢噻肟钠预防肝硬化上消化道出血患者并发肝性脑病的效果。82例肝硬化上消化道出血患者随机分为两组:预防组41例,给予头孢噻肟钠每次2g,每天3次,静脉注射,用至出血停止后3天。对照组41例,不用抗生素,其它止血、输血扩容等治疗两组相同。出血后3天,预防组血氨(67±17．49)μmol／L低于对照组(86．7±16．66)μmoL／L,t=5．16,P<0．01。预防组发生肝性脑病1例(2．4％),对照组11例(26．8％),x2=9．76,P< 0．01。死于肝性脑病者,预防组0例,对照组5例(12．2％),x2=5．32,P<0．05。头孢噻肟钠能有效预防肝硬化上消化道出血患者并发肝性脑病,改善预后。
To study the effect of cefotaxime on the prevention of hepatic encephalopathy in patients with cirrhosis and upper gastrointestinal bleeding. 82 patients with cirrhosis and upper gastrointestinal bleeding were randomly divided into two groups: prevention group of 41 cases, giving cefotaxime sodium 2g each time, 3 times a day, intravenous injection until bleeding stopped 3 days. The control group of 41 patients without antibiotics, other bleeding, blood transfusion and expansion of treatment of the same two groups. Blood ammonia (67 ± 17.49) μmol / L in the prophylaxis group was lower than that in the control group (86.7 ± 16.66) μmoL / L at 3 days after bleeding, t = 5.16, P <0.01. One case (2.4%) had hepatic encephalopathy in prevention group and 11 cases (26.8%) in control group, x2 = 9.76, P <0.01. Among the patients who died of hepatic encephalopathy, there were 0 in the prevention group and 5 in the control group (12.2%), x2 = 5.32, P <0.05. Cefotaxime sodium can effectively prevent hepatic cirrhosis patients with upper gastrointestinal hemorrhagic hepatic encephalopathy and improve prognosis.