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目的:探讨塞克硝唑治疗滴虫性泌尿生殖道感染的临床疗效。方法:将2011年1月至2012年12月诊治的泌尿生殖道滴虫感染患者68例随机分为观察组和对照组各34例。观察组应用塞克硝唑2 g顿服,一次为一疗程;对照组应用甲硝唑0.2/次,4次/日,一周为一疗程,结束疗程4~6日后复查,比较两组的临床疗效和不良反应。结果:观察组的痊愈率和总有效率分别为61.8%和94.1%,均显著高于对照组的38.2%和70.6%,P均<0.05;而观察组的总不良反应发生率5.8%明显低于对照组的38.2%,P<0.05。结论:与甲硝唑相比,塞克硝唑治疗泌尿生殖道滴虫感染不仅有效、安全,且使用方便,建议临床推广应用。
Objective: To investigate the clinical efficacy of Secnidazole in the treatment of trichomoniasis genitourinary tract infection. Methods: Sixty-eight patients with genitourinary tract trichomoniasis diagnosed and treated from January 2011 to December 2012 were randomly divided into observation group (34 cases) and control group (34 cases). The observation group applied siconazole 2 g Dayton clothing, once for a course of treatment; the control group metronidazole 0.2 / time, 4 times / day, one week for a course of treatment, the end of the course of treatment after 4 to 6 days review, the two groups of clinical Efficacy and adverse reactions. Results: The cure rate and total effective rate in the observation group were 61.8% and 94.1%, respectively, which were significantly higher than those in the control group (38.2% and 70.6%, P <0.05). However, the incidence of adverse reactions in the observation group was significantly lower than 5.8% 38.2% of the control group, P <0.05. Conclusion: Compared with metronidazole, seletronidase treatment of genitourinary tract trichomonas infection is not only effective, safe, and easy to use, it is recommended clinical application.