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目的探讨流感疫苗对慢性阻塞性肺病急性加重(AECOPD)的干预作用。方法分析62例稳定期COPD患者接种流感疫苗前后1年内AECOPD发作次数。结果流感疫苗接种后AECOPD发作率低于接种前(50.0%vs.72.6%)(P<0.05)。既往1年内需全身激素治疗的AECOPD是未来AECOPD和频繁AECOPD的独立危险因素。结论接种流感疫苗可减少AECOPD发作次数,在轻-中度气流受限患者中效果最佳。AECOPD患者既往1年内需全身激素治疗是一个简便、客观且可以预测未来急性加重风险的指标。
Objective To investigate the intervention effect of influenza vaccine on acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods The number of episodes of AECOPD in 62 stable COPD patients within one year before and after vaccination was analyzed. Results The incidence of AECOPD after influenza vaccination was lower than that before inoculation (50.0% vs 72.6%) (P <0.05). AECOPD requiring systemic hormonal therapy in the past year is an independent risk factor for future AECOPD and frequent AECOPD. Conclusions Vaccination with influenza vaccine can reduce the number of AECOPD episodes and work best in patients with limited light-to-moderate air flow. AECOPD patients with systemic hormone therapy in the past year is an easy, objective and can predict the risk of acute exacerbation in the future.