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目的观察抗抑郁治疗对不稳定型心绞痛伴抑郁患者近期预后的影响。方法将 5 6例不稳定型心绞痛伴抑郁的患者随机分为抗抑郁治疗组和对照组各 2 8例。治疗组在常规药物治疗基础上给予心理治疗及加服抗抑郁药氟西汀(百优解 ) 2 0mg/d ,顿服 ,疗程为 12周。结果治疗组与对照组比较 ,心肌缺血明显改善 (P <0 .0 5 ) ,心绞痛复发率及发生急性心肌梗死的比例低 (P <0 .0 5 )。结论抗抑郁治疗能明显改善不稳定型心绞痛伴抑郁患者的近期预后。
Objective To observe the effect of antidepressant on the short-term prognosis of patients with unstable angina pectoris and depression. Methods Fifty-six patients with unstable angina pectoris and depression were randomly divided into two groups: antidepressant treatment group and control group. The treatment group was given psychological treatment on the basis of routine drug treatment and the antidepressant plus fluoxetine (Baiyou Xie) 20mg / d, Dayton clothes, treatment for 12 weeks. Results Compared with the control group, the myocardial ischemia was significantly improved (P <0.05), the recurrence rate of angina pectoris and the incidence of acute myocardial infarction were lower (P <0.05). Conclusions Antidepressant therapy can significantly improve the short-term prognosis of patients with unstable angina pectoris and depression.