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他汀类药物又名羟甲基戊二酸单酰辅酶A(HMG-CoA)还原酶抑制剂,这类药物的作用机制是通过竞争性抑制内源性胆固醇合成限速酶(HMG-CoA)还原酶,阻断细胞内羟甲戊酸代谢途径,从而干扰内源性胆固醇合成,使细胞内胆固醇合成减少,从而反馈性刺激细胞膜表面(主要为肝细胞)低密度脂蛋白(low density lipoprotein,LDL)受体数量和活性增加、使血清胆固醇清除增加、水平降低。他汀类药物还可抑制肝脏合成载脂蛋白B-100,从而减少载脂蛋白A-V、脂蛋白的合成和分泌,目前
Statins, also known as hydroxymethyl glutaryl coenzyme A (HMG-CoA) reductase inhibitors, the mechanism of action of these drugs is by competitive inhibition of endogenous cholesterol synthesis rate-limiting enzyme (HMG-CoA) reduction Enzyme, blocking intracellular mevalonic acid metabolic pathway, thereby interfering with endogenous cholesterol synthesis, the reduction of intracellular cholesterol synthesis, and thus feedback stimulation of cell membrane surface (mainly liver cells) low density lipoprotein (LDL ) Receptor number and activity increased, so that serum cholesterol clearance increased, the level decreased. Statins also inhibit the liver synthesis of apolipoprotein B-100, thereby reducing the synthesis and secretion of apolipoprotein A-V, lipoproteins, at present