论文部分内容阅读
黄芪多糖(简称APS)是由阿拉伯糖和葡萄糖所组成,它具有较强的生物活性,给小鼠腹腔注射200mg/kg/天×7,能使脾脏显著增大,RNA含量增加,达18%左右。然而~3H-UR参入RNA的量显著性降低达81%。一次腹腔注射APS 500mg/kg,6小时后~3H-UR的参入即显著地降低,下降了45%。48小时后脾脏显著增大,RNA也略有增加,维持在10～14%,这些变化皆持续5天以上。其他网状内皮组织如肝脏及淋巴结,亦有类似作用,而胸腺、心、脑无明显作用。APS对DNA的代谢无明显的影响。已知结构的葡聚糖(MW15,000和150,000)对RNA代谢也有类似的作用,然作用强度不及APS。
Astragalus polysaccharide (APS) is composed of arabinose and glucose. It has strong biological activity. It can be injected into mice by intraperitoneal injection of 200mg/kg/day×7, which can increase the spleen significantly and increase the RNA content up to 18%. about. However, the amount of ~3H-UR incorporated RNA was significantly reduced by 81%. After an intraperitoneal injection of APS 500 mg/kg, the intake of ~3H-UR significantly decreased by 45% after 6 hours. After 48 hours, the spleen was significantly increased, RNA was also slightly increased and maintained at 10 to 14%. These changes lasted for more than 5 days. Other reticuloendothelial tissues such as the liver and lymph nodes also have similar effects, but the thymus, heart, and brain have no significant effect. APS has no apparent effect on DNA metabolism. The known structures of glucans (MW 15,000 and 150,000) also have a similar effect on RNA metabolism, but the effect is less than that of APS.