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目的探讨新诊断T2DM患者的胱抑素C(Cys-C)与血清胰升血糖素、C-P的关系。方法选取无高血压的新诊断T2DM患者91例,检测血糖、HbA1c、血脂、Cys-C等,行100g馒头餐试验,测定各点血清胰升血糖素、C-P水平,对C-P、Cys-C、胰升血糖素行多变量方差分析,以Cys-C为因变量行多元线性回归分析。结果多元线性回归分析显示,FC-P(β=0.301,P=0.000)、餐后2h胰升血糖素(β=-0.002,P=0.002)和BMI(β=-0.015,P<0.023)是新诊断T2DM患者中Cys-C的主要影响因素。结论新诊断T2DM患者Cys-C与FC-P呈正相关,与胰升血糖素、BMI呈负相关。
Objective To investigate the relationship between cystatin C (Cys-C) and serum glucagon and C-P in newly diagnosed T2DM patients. Methods Totally 91 newly diagnosed T2DM patients without hypertension were enrolled in this study. Blood glucose, HbA1c, lipids and Cys-C were measured in 100g steamed bread meal. Serum glucagon and CP levels at each point were measured. Multivariate analysis of variance was performed on glucagon, and multivariate linear regression analysis was performed using Cys-C as the dependent variable. Results Multivariate linear regression analysis showed that the values of FC-P (β = 0.301, P = 0.000), postprandial 2h glucagon (β = -0.002, P = 0.002) and BMI (β = -0.015, P <0.023) The main influencing factors of Cys-C in newly diagnosed T2DM patients. Conclusions There is a positive correlation between Cys-C and FC-P in newly diagnosed T2DM patients and a negative correlation with glucagon and BMI.