最近,已确认膳食蛋白质是影响血浆胆固醇的因素之一。在许多动物模型和人实验中观察到:动物蛋白膳食比植物蛋白膳食更易引起血浆胆固醇含量升高。动、植物膳食蛋白的致胆固醇血作用之间的差别是与其所含氨基酸成分有关。Krithersky等认为:膳食中动、植物蛋白对血浆胆固醇含量的作用不同,是膳食中精氨酸(Arg)与赖氨酸(Lys)比值不同造成的。他们发现,把Lys补充到植物蛋白饲料中或把Arg补充到动物蛋白饲料中,可明显改变家兔的胆固醇血对膳食蛋白的反应。在排尿素的哺乳动物,Arg的代谢反应是双向的。因为Arg不仅在尿素分解循环中是重要底物,也是合成 Recently, dietary protein has been identified as one of the factors that affect plasma cholesterol. It has been observed in many animal models and human experiments that animal protein diets are more likely to cause elevated plasma cholesterol levels than vegetable protein diets. Dynamic and plant dietary protein cholesterol-induced blood cholesterol differences between the amino acids contained in its composition. According to Krithersky et al., Dietary motility and plant protein have different effects on plasma cholesterol levels and are caused by different dietary ratios of arginine and lysine (Lys). They found that adding Lys into plant protein feed or supplementing Arg with animal protein feed significantly altered rabbit’s cholesterol blood response to dietary protein. In uremic mammals, Arg’s metabolic response is bidirectional. Because Arg is not only an important substrate but also a synthesis in the urea decomposition cycle