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自1981年Imbach等首先报道大剂量免疫球蛋白(lg)静滴治疗特发性血小板减少性紫癜(ITP)有效以来,各国学者对这方面的研究日益重视。现将目前大剂量Ie静滴有效的血液病扼要予以介绍。 一、大剂量Ig静滴治疗ITP Imbach等用大剂量多价完整的Ig静滴治疗7例慢性或间歇性ITP与6例急性ITP。全部病人的血小板值均于5天内明显上升,切脾者早期效应比未切脾者明显。急性ITP中2例需用Ig维持。经90～110天的观察,慢性ITP中有5例能单独用Ig使血小板维持足够水平。治疗中未见任何副作用。
Since 1981, Imbach et al. First reported that intravenous infusion of high-dose immunoglobulin (Ig) is effective in treating idiopathic thrombocytopenic purpura (ITP), scholars from various countries pay more and more attention to this aspect. At present, large doses of intravenous Ie effective blood diseases are briefly introduced. First, the high-dose intravenous infusion of Ig therapy ITP Imbach and other large doses of multivalent Ig intravenous infusion of seven cases of chronic or intermittent ITP and six cases of acute ITP. Platelet values of all patients were significantly increased within 5 days, the early effect of splenectomy was significantly more than those without splenectomy. 2 cases of acute ITP need to maintain with Ig. After 90 to 110 days of observation, 5 of the chronic ITPs were able to maintain adequate platelets with Ig alone. No side effects during treatment.