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目的:探讨凝血因子Ⅶ(FⅦ)浓度和凝血功能参数与产后出血的关系。方法:根据产后出血量对35例产后出血患者进行分组:产后出血量500~800ml 25例为1组,产后出血>800ml 10例为2组,在产前24h,对产后出血患者及110例正常生产孕妇进行FⅦ、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)和纤维蛋白原(Fbg)检测和分析。结果:1产后出血患者1组和2组FⅦ浓度均低于对照组,差异有统计学意义(P<0.05)。21组和2组PT、APTT明显高于对照组(P<0.01),1组Fbg低于对照组(P<0.05),2组Fbg明显低于对照组(P<0.01),TT与对照组比较差异无统计学意义(P>0.05)。3与1组比较,2组Fbg降低(P<0.05),FⅦ、PT、APTT和TT差异无统计学意义(P>0.05)。结论:产前检测临产孕妇FⅦ水平和凝血功能参数对预防及治疗产后出血有重要的临床参考价值。
Objective: To investigate the relationship between coagulation factor Ⅶ (FⅦ) concentration and coagulation parameters and postpartum hemorrhage. Methods: According to the amount of postpartum hemorrhage 35 cases of postpartum hemorrhage were grouped: postpartum hemorrhage 500 ~ 800ml 25 cases in 1 group, postpartum hemorrhage> 800ml 10 cases in 2 groups, prenatal bleeding in patients with postpartum hemorrhage and 110 cases of normal Pregnant women were tested for F Ⅶ, prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen (Fbg). Results: 1 The post-partum hemorrhage patients in group 1 and group 2 FⅦ concentrations were lower than the control group, the difference was statistically significant (P <0.05). The levels of PT and APTT in 21 and 2 groups were significantly higher than those in control group (P <0.01), Fbg in 1 group was lower than that in control group (P <0.05), Fbg in 2 groups was significantly lower than that in control group (P <0.01) The difference was not statistically significant (P> 0.05). 3 Compared with group 1, Fbg in 2 groups decreased (P <0.05), but there was no significant difference in FⅦ, PT, APTT and TT (P> 0.05). Conclusion: Prenatal testing of pregnant women with FⅦ levels and coagulation parameters to prevent and treat postpartum hemorrhage have important clinical reference value.