目的 应用失血、感染双重因素制作了大鼠多器官功能衰竭(MODS)模型,研究胃肠道激素的变化。方法对大鼠MODS及MOF模型进行胃肠道组织病理学观察,胃液pH、血浆胃泌素和胃动素检测。结果 MODS及MOF大鼠模型胃肠道粘膜受损,胃酸pH值下降,血浆胃泌素、胃动素水平升高。结论 血浆胃肠激素水平可能是影响MODS个体胃肠道及全身疾病发生、发展的重要因素。 Objective To establish a model of multiple organ failure (MODS) in rats and study the changes of gastrointestinal hormones using the dual factors of blood loss and infection. Methods The pathological changes of gastrointestinal tract, gastric juice pH, plasma gastrin and motilin in MODS and MOF of rats were observed. Results MODS and MOF rat model of gastrointestinal mucosa damage, gastric pH decreased, plasma gastrin, motilin levels increased. Conclusion The level of plasma gastrointestinal hormones may be an important factor affecting the occurrence and development of gastrointestinal and systemic diseases in MODS individuals.