男性患胶质瘤的风险比女性高,但确切机制仍不清楚。最近的流行病学和基因分型研究认为这种发生率的性别差异是由于雄激素受体(AR)在体内的异常表达,而且以往的研究也表明AR在胶质瘤中过度表达,是一个独立的不良预后因子。因此,AR可能在脑胶质瘤的发生发展中发挥着重要作用。此外,越来越多的证据表明AR参与的许多信号通路与脑胶质瘤的发生有关。在此基础上,本文就AR与胶质瘤的关系以及相关的作用机制作简要综述。 Men are at higher risk of developing gliomas than women, but the exact mechanism remains unclear. Recent epidemiological and genotypic studies suggest that the gender difference in this incidence is due to the abnormal expression of the androgen receptor (AR) in vivo and previous studies have also shown that AR is overexpressed in glioma and is a Indirect adverse prognostic factors. Therefore, AR may play an important role in the development of glioma. In addition, there is a growing body of evidence that many of the signaling pathways involved in AR are involved in the pathogenesis of gliomas. On this basis, this article briefly reviews the relationship between AR and gliomas and related mechanisms.