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自1961年在Framingham随访6年的报告中首次提出了“危险因素”这个词以来,欧洲、美国和亚洲又进行了多项前瞻性队列研究,一致证明了冠心的三大危险因素:高血压、高血清总胆固醇(或低密度脂蛋白胆固醇)及吸烟与冠心病发病有因果关系[1]。20世纪80年代以来又有了一个新的前瞻性研究高潮,不仅证实了一些的危险因素,而且对上述三大危险因素有了深入细致地定量分析,从而加深了对其致病作用的认识,纠正了许多可用的观念,不仅对心血管病的预防策略,而且对整个心脏病学起了观念更新的作用。
A number of prospective cohort studies have been conducted in Europe, the United States, and Asia since the first “Crisis” term in 1961 following a six-year Framingham follow-up report that unanimously demonstrated the three major risk factors for coronary heart disease: Hypertension, high serum total cholesterol (or low-density lipoprotein cholesterol) and smoking have a causal relationship with the incidence of coronary heart disease [1]. Since the 1980s, there has been a new upsurge in prospective research, not only confirming some of the risk factors, but also the above three risk factors have been intensively and quantitatively analyzed, thus deepening their understanding of the pathogenic role, Corrected many of the available concepts, not only for cardiovascular disease prevention strategies, but also for the entire cardiology played a role in the concept of update.