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目的观察小剂量丙戊酸与拉莫三嗪联合治疗新诊断癫痫的临床疗效及安全性。方法将102例患者随机分为观察组与对照组,两组患者病程均为3~12个月。于治疗前及治疗后3、6个月评估患者的发作频率、控制效果及不良反应发生情况,根据三种指标参数变化评估患者病情变化。结果小剂量丙戊酸与拉莫三嗪联合治疗新诊断癫痫的临床疗效优于单药治疗的效果;小剂量丙戊酸与拉莫三嗪联合治疗新诊断癫痫的不良反应略高于单药治疗,差异未见统计学的意义(P>0.05)。结论小剂量丙戊酸与拉莫三嗪联合治疗新诊断癫痫的临床疗效优于单药用药的效果,且该治疗方法具有安全性,是一种值得推广的癫痫病临床治疗方法。
Objective To observe the clinical efficacy and safety of low dose valproic acid combined with lamotrigine in the treatment of newly diagnosed epilepsy. Methods 102 patients were randomly divided into observation group and control group. The course of disease in both groups was 3 to 12 months. The patients ’seizure frequency, control effect and adverse reactions were evaluated before treatment and 3, 6 months after treatment. The changes of patients’ condition were evaluated according to the changes of three index parameters. Results Small dose of valproic acid combined with lamotrigine in the treatment of newly diagnosed epilepsy was superior to monotherapy in the clinical efficacy of small doses of valproic acid combined with lamotrigine treatment of newly diagnosed epilepsy adverse reactions slightly higher than the single drug Treatment, the difference was not statistically significant (P> 0.05). Conclusions The combination of low dose valproic acid and lamotrigine is superior to monotherapy in the treatment of newly diagnosed epilepsy. The method is safe and is worthy of promotion in the clinical treatment of epilepsy.