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青霉素由于发酵技术的提高,以及固相酶裂解工艺的成功,价格不断降低,因而在β-内酰胺抗生素中新的半合成青霉素无论在品种和产量上都居第一位。在6-APA C_6位,用不同酰胺侧链形成的新青霉素,在临床疗效上已取得了很大的成就。近年来由于化学合成水平不断提高,以及分离分析新技术的应用,对整个青霉素分子(Penicillin Molecular)结构的研究也取得了更大的进展,为青霉素的化学研究增添了新的贡献和内容。本文就青霉素结构中的β-内酰胺环,以及噻唑烷的化学改变作一简略介绍。
Because of the improvement of fermentation technology and the success of the solid-phase enzyme lysis process, the price of penicillin keeps decreasing. Therefore, the new semi-synthetic penicillin in the β-lactam antibiotics occupies the first place both in variety and yield. In the 6-APA C_6 position, with different amide side chain formation of new penicillin, has achieved great clinical success. In recent years, due to the increasing level of chemical synthesis and the application of new techniques for separation and analysis, more progress has been made in the study of the structure of the entire penicillin molecule, thus adding new contributions and contents to the chemical research of penicillin. In this paper, the structure of penicillin β-lactam ring, as well as the chemical changes of thiazolidine for a brief introduction.