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布鲁菌病的主要病源菌是胞内马尔他布鲁氏菌。此病广泛流行于地中海盆地和南美,而且据报道近年来发病率有所增加。此病最初症状变化不定而无诊断学特征。但有几方面可供鉴别:累及骨骼及中枢神经系统,也可以累及其他的潜伏部位,而这些部位能保护微生物使其免受抗体、免疫活性细胞及抗生素的攻击,于是复发率高。早先,世界卫生组织推荐的药物治疗方案是合用四环素3周和链霉素2周。复发率在15%～26%范围内。延长服用四环素的时间至30～45d,医治失败或复发的病人数可以减少至2.5%～
Brucellosis is the main source of bacteria intracellular Brucella brucellosis. The disease is widespread in the Mediterranean basin and South America, and the incidence has reportedly increased in recent years. The initial symptoms of the disease change uncertain and no diagnostic features. However, there are several aspects to be identified: involving the bones and the central nervous system, but also involving other latent sites, which can protect microorganisms from antibodies, immune cells and antibiotics attack, so the recurrence rate. Earlier, the WHO recommended drug regimens were tetracycline for 3 weeks and streptomycin for 2 weeks. The recurrence rate in the range of 15% to 26%. Extend the time taking tetracycline to 30 ~ 45d, the number of patients who failed to cure or relapse can be reduced to 2.5% ~