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重型肝炎病情进展迅速,病死率甚高,微循环障碍是肝细胞进一步坏死及各种并发症的重要病理生理基础,其中血小板的活化参与了这一病理过程。近年来,国内外学者对重型肝炎患者的血小板功能,作了一些研究,试图阐明血小板的功能状态与重型肝炎及其并发症的关系,但各家报道不一。为此,我们检测了慢性重型肝炎(慢重型)患者血浆内血小板。颗粒膜蛋白(GMP-140)和血管性假血友病因子相关抗原(vWF:Ag)水平。同时用脉络宁治疗后观察上述指标的变化,以了解该病早期血小板和内皮细胞功能的变化及脉络宁对两者的影响。
Severe hepatitis progresses rapidly and mortality is very high. Microcirculation disorder is an important pathophysiological basis for further necrosis of hepatocytes and various complications, of which platelet activation is involved in this pathological process. In recent years, domestic and foreign scholars on platelet function in patients with severe hepatitis, made some research, trying to clarify the functional status of platelets and severe hepatitis and its complications, but various reports vary. To this end, we examined the plasma platelet count in patients with chronic severe hepatitis (slow-acting). Granular membrane protein (GMP-140) and von Willebrand factor-associated antigen (vWF: Ag) levels. At the same time treated with Mailuoning the changes in the above indicators to understand the disease early platelet and endothelial cell function changes and Mailuoning the impact on both.