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１２０例以顺铂或阿霉素联合方案化疗的肿瘤患者，应用盐酸恩丹西酮与胃复安进行自身随机对照止吐研究。前者预防顺铂方案引起的急性呕吐，第１，２，３天有效率分别为９５．８％，９１．１％及８９．５％，后者分别为５６．３％，７５％及７７．１％；对非顺铂方案引起的呕吐，恩丹西酮１，２，３天有效率均为９５．８％，胃复安第１，２天有效率为８７．５％，第３天有效率为８８．９％。恩丹西酮的主要副作用是便秘，无锥体外系反应。结论：恩丹西酮止呕疗效高，副作用小，尤其适合于顺铂所致的急性呕吐。
In 120 cancer patients treated with cisplatin or doxorubicin combined chemotherapy, ondansetron hydrochloride and metoclopramide were used to conduct randomized controlled antiemetic studies. The former to prevent acute vomiting caused by cisplatin regimen, the effective rates were 95.8%, 91.1% and 89.5% on the 1st, 2nd and 3rd days respectively, and the latter were 56.3%, 75% and 77.7% respectively. 1%; For vomiting caused by the non-cisplatin regimen, the onset rate of ondansetron was 1,2,3 days, 95.8%; on the 1st and 2nd days of the metoclopramide, the effective rate was 87.5%, the 3rd day The effective rate is 88.9%. The main side effect of ondansetron is constipation and no extrapyramidal reactions. Conclusion: Ondansetron has high antiemetic efficacy and side effects, and is especially suitable for acute vomiting caused by cisplatin.