α-溴代酰胺和亲电氰化试剂在锌粉存在条件下转化为相应的含有季碳中心的α-氰基酰胺和烯酮亚胺锌中间体;向反应体系中引入亲电试剂捕获该中间体,顺利得到另一种含有季碳中心的氰基产物,实现了一锅法合成两种含有季碳中心的氰基化合物.该反应体系可以构建含有碳-碳、碳-硫或碳-氟键的季碳中心.该方法可用于关键药物中间体如洛哌丁胺、普罗地芬、维拉帕米、戈洛帕米、α-氟代布洛芬以及α-氟代氟比洛芬的形式合成,体现了其潜在应用价值.“,”α-Bromocarboxamides and electrophilic cyanide reagent were transformed into the corresponding α-cyano-carboxamides and ketene imine zinc intermediate in the presence of Zn reductant.Trapping of such Zn species with additional electrophiles resulted another type of nitriles,which realized the synthesis of two types of nitriles both bearing quaternary carbon centers in one-pot manner.This approach could be used to construct C—C,C—S,or C—F bond.Formal synthesis of several key pharmaceutical intermediates including loperamide,proadifen,verapamil,and gallopamil as well as α-fluoro-ibuprofen and α-fluoroflurbiprofen demonstrated the potential application of this methodology.