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目的:识别双黄连注射剂国内研究的热点及热点的演变趋势。方法:检索中国期刊论文全文数据库,运用文献计量可视化软件Cite Space,绘制了1992年—2015年双黄连注射剂期刊文献的关键词图谱,在此基础上,探讨了共现关键词网络结构特征、主要聚类、类标签命名及代表性关键词。结果:双黄连注射液关键词网络模块结构显著(Q=0.712 7),聚类结果的可信度较高(Mean Sihouette=0.671 7),主要聚类包括:生物热活性图谱(#0),瞳孔等大(#1),医院制剂室(#2),呼吸困难(#3),肠蠕动(#4),丹参粉针(#5),采用tf*idf算法命名聚类标签。从频次、突发性指标评估得到的代表性关键词有:双黄连粉针剂,双黄连注射剂,不良反应,绿原酸,黄芩苷,影响因素。结论:注射用双黄连的文献研究,探讨的主题集中在不良反应研究领域。结合目前中药注射剂不良反应发生率较高的现状和对网络突变性节点的定量分析结果,预测注射用双黄连不良反应的影响因素研究将是未来的新兴趋势。
OBJECTIVE: To identify the hot spots and trends in the development of Shuanghuanglian injection. Methods: The full-text database of Chinese journal articles was searched. The key word map of Shuanghuanglian injection periodicals literature was drawn up by using Cite Space, a literature review visualization software. On this basis, the key words of the co-occurrence keywords network structure were discussed, mainly Clustering, class label naming and representative keywords. Results: The structure of key words of Shuanghuanglian injection was significant (Q = 0.712 7). The clustering results were highly credible (Mean Sihouette = 0.671 7). The main clustering included: bioactivity map, (# 1), hospital preparation room (# 2), dyspnea (# 3), peristalsis (# 4) and salvia miltiorrhiza (# 5) were clustered using the tf * idf algorithm. From the frequency, sudden index evaluation of the representative keywords are: Shuanghuanglian injection, Shuanghuanglian injection, adverse reactions, chlorogenic acid, baicalin, the impact of factors. Conclusion: The literature of Shuanghuanglian for injection has focused on the field of adverse reaction research. Combined with the current situation of high incidence of adverse reactions of traditional Chinese medicine injection and the quantitative analysis results of the network mutant nodes, it is a new trend to predict the influencing factors of Shuanghuanglian injection adverse reactions in the future.