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在离体正常和炎性胆囊，甲基莲心碱（Ｎｅｆ）明显抑制Ｋ＋所致收缩，其ＩＣ（５０）分别为１２０μｍｏｌ／Ｌ和５μｍｏｌ／Ｌ，表明Ｎｅｆ对炎性胆囊抑制作用较强。Ｎｅｆ和维拉帕米（Ｖｅｒ）可抑制Ｋ￣＋所致Ｏｄｄｉ括约肌两相收缩，Ｖｅｒ主要抑制持久相收缩，而Ｎｅｆ以抑制时相收缩为强。Ｎｅｆ和Ｖｅｒ非竞争性拮抗组织胺（Ｈｉｓｔ）所致胆囊收缩，其ＰＤ′＿２值分别为５．０１和５．３８。提示Ｎｅｆ对胆道平滑肌的抑制作用与其抗内钙释放有关。
In isolated normal and inflammatory gallbladder, neferine significantly inhibited the contraction caused by K+, and its IC (50) was 120 μmol/L and 5 μmol/L, respectively, indicating that Nef has a strong inhibitory effect on inflammatory gallbladder. Nef and verapamil (Ver) inhibited the contraction of Oddi’s sphincter contraction caused by K ̄ + , Ver inhibited the contraction of the permanent phase, and Nef suppressed the contraction of the time phase. Nef and Ver non-competitively antagonized the contraction of the gallbladder caused by histamine (Hist) with PD’2 values of 5.01 and 5.38, respectively. It is suggested that the inhibitory effect of Nef on bile duct smooth muscle is related to its resistance to internal calcium release.