患者,男,66岁。因咳嗽,咯血丝痰1个月,于1998年2月3日入院,经胸片、胸CT、纤支镜活检,诊断为左肺癌,低分化鳞癌,Ⅲb期。住院3天后出现尿急、尿频、尿痛,尿常规结果:白细胞(?)/HP,脓细胞(++)/HP,外周血白细胞15.6×10~9/L,中性0.82,按经验选用多种抗生素治疗无效。2次中段尿细菌培养,均培养出金黄色葡萄球菌(简称金葡菌),且菌落数＞10~8/L,药敏试验结果为:对青霉素、氧哌嗪青霉素、邻氯青霉素、双氯青霉素、苯甲异恶唑青霉素、氨苄青霉素、先锋霉素V、先锋霉素Ⅵ,先锋必、菌必治、复达欣、庆大霉素、卡那霉素、丁胺卡那霉素、红霉素、氯霉素、氟哌酸、氟嗪酸、环丙沙星和复方新诺明等均耐药,仅对万古霉素敏感。因缺此药,试用平阳霉素治疗。方法:平阳霉素8mg肌注,每天2次,共15天,期间未用其他抗生素。结果:平阳霉素治疗3天后患者尿频、尿痛症状减轻,第5天时这些症状全部消失,第10天复查尿常规及血常规结果均正常。不良反应:用药后出现恶心、呕吐,停药之天后,这些症状消失。 Patient, male, 66 years old. Due to cough, hemoptysis sputum for 1 month, on February 3, 1998 admission, the chest radiography, chest CT, bronchoscopy biopsy, diagnosed as left lung cancer, poorly differentiated squamous cell carcinoma, Ⅲ b period. Urgency, frequent urination, dysuria and urine were observed after 3 days in hospital. The results of routine tests were as follows: white blood cell (?) / HP, pus (++) / HP, peripheral blood leukocyte 15.6 × 10 ~ 9 / A variety of antibiotic treatment is invalid. Staphylococcus aureus (Staphylococcus aureus) was cultured twice in the middle stage of urine bacterial culture, and the number of colonies was more than 10 ~ 8 / L. The results of drug sensitivity test were as follows: for penicillin, piperacillin penicillin, Penicillin, penicillin, cephalosporin, cephalosporin V, cephalosporin V, vanguardmycin Ⅵ, vanguard will, bacteria must rule, Fu Daxin, gentamicin, kanamycin, amikacin , Erythromycin, chloramphenicol, norfloxacin, flurazin acid, ciprofloxacin and cotrimoxazole etc. are resistant to vancomycin only. Due to lack of this drug, trial Pingyangmycin treatment. Methods: Pingyangmycin 8mg intramuscular injection, 2 times a day for a total of 15 days, during which no other antibiotics. Results: The symptoms of pollakiuria and dysuria were relieved 3 days after treatment with Pingyangmycin. All the symptoms disappeared on the 5th day. On the 10th day, urinalysis and routine blood tests were normal. Adverse reactions: nausea, vomiting after treatment, withdrawal days, these symptoms disappear.