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舒肝祛脂胶囊是新华医院的院内中药复方制剂,临床主要用于脂肪肝引起的转氨酶升高和肝内脂肪浸润、肥胖、高血脂等疾病治疗.本研究对舒肝祛脂胶囊在成人单纯性肥胖症中的临床疗效及安全性进行考察.将符合纳入标准的患者随机分成观察组和对照组,在相同的营养咨询和饮食干预下分别给予药物治疗,疗程均为2个月,治疗前后分别观察体质量、体质量指数(BMI)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、丙氨酸转氨酶(ALT)、天门冬氨酸转氨酶(AST)、尿素氮(BUN)、肌酐(Cr)、尿常规、血常规等指标变化情况.研究结果显示舒肝祛脂胶囊治疗组总有效率为66.67％,并且治疗前后患者的体重和体重指数变化分别存在显著差异(P＜0.01).对于肥胖患者的血脂代谢,总胆固醇、甘油三酯、高密度脂蛋白和低密度脂蛋白水平较治疗前略有下降,但是没有统计学差异(P＞0.05).对照组总有效率为39.13％,治疗前后患者的体重和体重指数变化分别存在显著差异(P＜0.01).组间比较无显著性差异(P＞0.05).两组患者肝功能、肾功能、尿常规、血常规治疗前后无明显变化.结果提示舒肝祛脂胶囊对成人单纯性肥胖具有一定的减肥效果,且无明显不良反应.“,”Shugan Quzhi capsule is a hospital preparation of Xinhua Hospital affiliated to School of Medicine,Shanghai Jiaotong University.It has been used to treat adult patients with fatty liver caused by obesity,high cholesterol and other factors.In the present study,we investigated the clinical efficacy and safety of Shugan Quzhi capsule in adult simple obesity.The patients were randomly divided into the treatment group and control group.The whole treatment lasted 2 months under the same nutritional condition and diet intervention.Body weight,body mass index,total cholesterol,triglyceride,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,alanine aminotransferase,aspartate aminotransferase,blood urea nitrogen,creatinine,urine and blood routine examination were recorded before and after treatment.Our data showed that the total effective rate of treatment group was 66.67％,and body weight and body mass index after treatment the body were significantly decreased (P＜0.01).The levels of total cholesterol,triglyceride,high-density lipoprotein and low-density lipoprotein after treatment were lower than before treatment,but there was no statistical difference (P＞0.05).The total effective rate of control group was 39.13％,and the body weight and body mass index after treatment were also significantly lower than before (P＜0.01).There was no significant difference between the treatment group and control group (P＞0.05).There were no significant changes in liver function,renal function,urine routine and blood routine examination data after treatment.The results suggested that Shugan Quzhi capsule had certain therapeutic efficacy and safety in adult simple obesity.