论文部分内容阅读
以透明质酸（ＨＡ）和层粘素（ＬＮ）为非胶原性间质成份的代表，观察其对大鼠培养肝实质细胞和人胎肝细胞￣３Ｈ－胸腺嘧啶核苷（￣３Ｈ－ＴｄＲ）和￣３Ｈ－脯氨酸（￣３Ｈ－Ｐｒｏ）掺入的影响。结果表明，正常血清浓度的ＨＡ和ＬＮ对肝细胞无明显的影响，高浓度则显著抑制￣３Ｈ－ＴｄＲ及￣３Ｈ－Ｐｒｏ的掺入，但抑制程度和剂量递增无显著相关性。
Hyaluronic acid (HA) and laminin (LN) as a non-collagen interstitial components of the representative observed in rats cultured liver parenchymal cells and human fetal hepatocytes ~ 3H-thymidine (~ 3H-TdR ) And ~ 3H-proline (~ 3H-Pro) incorporation of the impact. The results showed that the normal serum concentration of HA and LN had no significant effect on the hepatocytes. High concentration significantly inhibited the incorporation of 3H-TdR and 3H-Pro, but there was no significant correlation between the inhibition and dose escalation.