【摘 要】
：
The combination of intracytoplasmic sperm injection (ICSI) with artificial oocyte activation has overcome repeated fertilization failure after ICSI due to sperm
【机 构】
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Reproductive Medical Center, Peking University People’s Hospital, Beijing 100044, China “,”Key Labor
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The combination of intracytoplasmic sperm injection (ICSI) with artificial oocyte activation has overcome repeated fertilization failure after ICSI due to sperm defects in activating oocyte,resulting in pregnancies and births for many couples.1-3 However,in comparison to the growing data illustrating the effectiveness of artificial oocyte activation in reproductive medicine,the safety of this approach has not been well studied.Previously,we demonstrated that the activated embryos derived from unfertilized oocytes after ICSI could develop to blastocyst stage,similar to normal embryos,as evidenced by dual color fluorescence in situ hybridization (FISH) on sex chromosomes.3 However,before artificial oocyte activation is accepted as a clinical strategy,further safety studies of the offspring need to be carefully evaluated.
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