BCG为现今世界上广泛用于预防结核病的疫苗,但对儿童和成人肺结核的预防作用不稳定,而且效果通常较差。目前有许多BCG分离株应用于商业疫苗的生产,这些分离株都是通过反复体外传代培养而成,具有不同的遗传特性,对动物感染模型的毒力也不同。有研究表明,BCG株和接种途径的不同会 BCG is the most widely used vaccine in the world today for the prevention of tuberculosis, but its preventive effect on children and adults is not stable and the effect is usually poor. At present, many BCG isolates are used in the commercial production of vaccines. These isolates are obtained through repeated in vitro subcultures with different genetic characteristics and virulence to animal models of infection. Studies have shown that BCG strains and vaccination routes will be different