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本文作者用荧光测定法观察57例原发性高血压病病人(其中Ⅰ期13例,Ⅱ期20例,Ⅲ期24例)血小板5-羟色胺(5-HT)和血浆5-羟吲哚类物质(5-HIs),并对其机理进行了探讨。结果:高血压病病人血小板5-HT含量明显低于正常人,作者推测与循环钠泵抑制物有关。在高血压并发急性脑血管意外者同时观察到血小板5-HT降低和血浆5-HTs升高,这与体内血小板激活有关。36例资料完整的高血压病人血浆尿素氮
In this study, 57 patients with essential hypertension (including 13 cases of stage Ⅰ, 20 cases of stage Ⅱ and 24 cases of stage Ⅲ) were observed by fluorimetric assay. Serum 5-hydroxytryptamine (5-HT) and 5-hydroxyindoles Material (5-HIs), and its mechanism was discussed. Results: The content of platelet 5-HT in patients with essential hypertension was significantly lower than that in normal subjects. The authors speculate that circulating sodium pump inhibitors are involved. In patients with hypertension complicated by acute cerebrovascular accident, both platelet 5-HT reduction and plasma 5-HTs elevation were observed, which is associated with platelet activation in vivo. Thirty-six patients with intact hypertensive patients had plasma urea nitrogen