巨噬细胞(ΜΦ)的非特异细胞毒效应在体外作用短暂,作者的研究工作表明:正是ΜΦ自己合成分泌的前列腺素E(PGE)抑制了其自身的细胞毒活性。方法:①ΜΦ细胞毒实验:获得正常C3He/HeN 小鼠腹腔ΜΦ,将单层ΜΦ与细菌脂多糖(LPS)予培养(浓度100ng/ml)若干时间,激活ΜΦ,在各 The non-specific cytotoxic effects of macrophages (ΜΦ) are transient in vitro. The author’s research shows that it is the prostaglandin E (PGE) secreted by ΜΦ itself that inhibits its own cytotoxic activity. METHODS: 1 Μ Φ Cytotoxicity test: The C3 He/HeN mice were given peritoneal Μ Φ, and the monolayer Μ Φ and bacterial lipopolysaccharide (LPS) were pre-incubated (concentration 100 ng/ml) for a certain period of time to activate Μ Φ, in each