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本文观察新生儿感染性疾病时血清急相蛋白的变化。结果表明:急性感染时血清CRP、α-AGP、α_1-AT增高,其中CRP对炎症反映比α_1-AGP、α_1-AT敏感,随炎症控制血清CRP迅速下降、α_1-AGP、α_1-AT在血中持续时间较CRP长,下降较缓慢。负性急相蛋白中前蛋白在感染时下降,随病情好转而上升,对炎症反映不如正性急相蛋白敏感。临床上对新生儿感染性疾病,必须联合测定急相蛋白才能做出早期诊断并指导抗生素疗程和估计预后。
This article observes changes in serum acute phase protein in neonatal infectious diseases. The results showed that the serum levels of CRP, α-AGP and α_1-AT were increased during acute infection, of which CRP was more sensitive to inflammation than α_1 -AGP and α_1-AT. Serum levels of CRP decreased with the severity of inflammation. In duration longer than the CRP, decline more slowly. Preprotein negative negative phase protein in the infection decreased, with the condition improved and the inflammatory response is not as good as the positive phase sensitive protein. Clinically for neonatal infectious diseases, the combination of acute phase protein must be combined to make early diagnosis and guide the course of antibiotics and prognosis.