为了解吡喹酮脂质体的包封率及其稳定性，以便为兽医临床使用该制剂提供依据，采用逆向蒸发法制备了粒径为６～１０ｎｍ的吡喹酮小单层脂质体，并获得了６０％以上的药物包封率，灭菌后脂质体在４℃冰箱中保存，贮存６０ｄ，其包封率基本保持稳定状态 In order to understand the entrapment efficiency and stability of praziquantel liposomes in order to provide a basis for the veterinary clinical use of the preparation, praziquantel small-size liposomes with particle size of 6 ~ 10nm were prepared by reverse evaporation method. And the drug encapsulation efficiency of more than 60% was obtained. After sterilization, the liposomes were stored in a refrigerator at 4 ° C for 60 days, and the encapsulation efficiency remained basically stable