论文部分内容阅读
观察了三黄糖肾安片对腹腔注射STZ4周后诱发的糖尿病大鼠早期肾脏病变的治疗作用。结果表明,三黄糖肾安片能降低糖尿病的肾重及肾重/体重比值,减少尿微量白蛋白(Alb)及B2-微球蛋白(B2-MG)的排泄,降低尿N-乙酰-B-D氨基葡萄糖苷酶(NAG)的活性,并能降低血糖、血脂及肌酐(Scr)和尿素氮(BUN),减少肾小球基底膜(GBM)厚度。提示三黄糖肾安对糖尿病大鼠早期肾脏功能及结构均有良好的改善作用。
The effect of Sanhuang Tangshenian Tablet on the early renal lesions induced by intraperitoneal injection of STZ for 4 weeks was observed. The results showed that Sanhuang Tang Shenan Tablets can reduce the ratio of kidney weight and kidney weight/body weight in diabetic patients, reduce excretion of urinary microalbumin (Alb) and B2-microglobulin (B2-MG), and reduce urinary N-acetyl- BD glucosidase (NAG) activity, and can reduce blood glucose, blood lipids and creatinine (Scr) and urea nitrogen (BUN), reduce glomerular basement membrane (GBM) thickness. It is suggested that Sanhuangshen Shenan can improve the early kidney function and structure of diabetic rats.