论文部分内容阅读
目前对自发性蛛网膜下腔出血后迟发性脑血管痉挛尚缺乏有效的预防和治疗方法。近年来,胰岛素的血管活性作用正逐渐引起人们的重视。胰岛素可降低蛛网膜下腔出血后产生的高血糖,抑制高血糖对血管内皮细胞和脑组织的损害,并通过Ras-促分裂原活化蛋白激酶(MAPK)途径促进内皮细胞的修复。同时,胰岛素还通过磷脂酰肌醇3激酶-蛋白激酶B(PI3K-PKB)信号通路作用于内皮细胞,产生一氧化氮,抑制血管收缩,增加缺血区域的血流。本文对此进行综述。
At present, there is no effective prevention and treatment for delayed cerebral vasospasm after spontaneous subarachnoid hemorrhage. In recent years, the vasoactive effect of insulin is gradually aroused people’s attention. Insulin reduces the hyperglycemia produced after subarachnoid hemorrhage, inhibits the damage of hyperglycemia to vascular endothelial cells and brain tissue, and promotes endothelial cell repair via the Ras-mitogen-activated protein kinase (MAPK) pathway. In the meantime, insulin also acts on endothelial cells via the phosphatidylinositol 3-kinase-protein kinase B (PI3K-PKB) signaling pathway, producing nitric oxide, inhibiting vasoconstriction and increasing blood flow in the ischemic area. This article summarizes this.