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目的 探讨细胞凋亡在胰腺癌形成发展过程中的作用。方法 采用原位末端标记法对 32例胰腺癌和 14例慢性胰腺炎中的细胞凋亡进行测定。结果 慢性胰腺炎的细胞凋亡数明显低于胰腺癌的细胞凋亡数 (P <0 .0 1) ,胰腺低分化腺癌和 TNM分期 、 期的细胞凋亡数低于高分化腺癌和 TNM分期 、 期的细胞凋亡数 (P<0 .0 5 )。结论 细胞凋亡在胰腺癌发生发展中起重要作用 ,可以作为预测胰腺癌病程和预后的指标
Objective To investigate the role of apoptosis in the development of pancreatic cancer. Methods Apoptosis in 32 cases of pancreatic cancer and 14 cases of chronic pancreatitis was determined by in situ end labeling. Results The number of apoptotic cells in chronic pancreatitis was significantly lower than that in pancreatic adenocarcinoma (P <0.01). The numbers of apoptotic cells in poorly differentiated pancreatic adenocarcinoma and TNM stage were lower than those in well-differentiated adenocarcinoma and adenocarcinoma TNM staging, the number of apoptosis (P <0.05). Conclusions Apoptosis plays an important role in the development of pancreatic cancer and can be used as an index to predict the course and prognosis of pancreatic cancer