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目的:对药学干预对2型糖尿病患者用药依从性及药品不良反应的影响进行探讨。方法:选取2015年1月-2016年4月于我院内科收治的130例2型糖尿病患者作为研究对象,采取双盲法将其随机分为对照组(65例)与观察组(65例),对照组采取临床常规用药干预,观察组采取药学干预,比较两组患者用药依从性及药品不良反应发生情况。结果:观察组用药总依从性98.46%相较于对照组78.46%差异显著,P<0.05;观察组共发生11例(16.92%)药品不良反应,9例(13.85%)发生用药偏差相较于对照组24例(36.92%)、19例(29.23%)差异显著,具有统计学意义(X2=6.608、4.552,P<0.05);两组患者入院时空腹血糖及餐后2h血糖比较无显著差异,P>0.05;观察组患者出院时空腹血糖(6.1±1.2)、餐后2h血糖(8.3±1.8)相较于对照组(7.0±1.5)、(11.7±2.1)差异显著,P<0.05。结论:药学干预能够显著提高2型糖尿病患者用药依从性,降低患者用药偏差、不良反应发生率,提高其血糖控制效果,具有推广应用价值。
Objective: To investigate the influence of pharmacy intervention on drug compliance and adverse drug reactions in patients with type 2 diabetes mellitus. Methods: A total of 130 type 2 diabetic patients admitted to our hospital from January 2015 to April 2016 were enrolled in this study. They were randomly divided into control group (65 cases) and observation group (65 cases) by double-blind method. , The control group to take clinical routine intervention, the observation group to take a pharmacy intervention, the two groups of patients compliance and drug adverse reactions were compared. Results: The total compliance of the observation group was 98.46% compared with that of the control group 78.46%, P <0.05; 11 patients (16.92%) adverse reactions in the observation group and 9.8% (13.85%) in the observation group compared with the control group There were significant differences between the two groups (24.92%) and 19 cases (29.23%) with statistical significance (X2 = 6.608,4.552, P <0.05). There was no significant difference in fasting blood glucose and postprandial blood glucose between the two groups , P> 0.05. The fasting blood glucose (6.1 ± 1.2) and 2h postprandial blood glucose (8.3 ± 1.8) in the observation group were significantly different from those in the control group (7.0 ± 1.5) and (11.7 ± 2.1), P <0.05. Conclusion: Pharmacological intervention can significantly improve compliance of patients with type 2 diabetes mellitus, reduce patients’ medication deviation and incidence of adverse reactions and improve their blood sugar control effect, which has the value of popularization and application.