目的　探索表皮生长因子 (EGF)在消化性溃疡发病中的作用。方法　用放免法测定以比较健康对照组、胃溃疡、十二指肠球溃疡病人的胃液中EGF的浓度。结果　活动期十二指肠球溃疡和胃溃疡患者胃液中的EGF水平明显低于对照组 (分别是P <0 .0 0 1 ,P <0 .0 1 ) ,而且非活动期十二指肠球溃疡比对照组亦低 (P <0 .0 0 1 ) ;但非活动期胃溃疡无此区别 (P >0 .0 5)。结论　EGF的减少在消化性溃疡的发病机理中起一定作用。 Objective To explore the role of epidermal growth factor (EGF) in the pathogenesis of peptic ulcer. Methods The radioimmunoassay method was used to compare the concentration of EGF in the gastric juice of healthy controls, gastric ulcer and duodenal ulcer patients. Results The levels of EGF in gastric juice of patients with active duodenal ulcer and gastric ulcer were significantly lower than those of the control group (P <0.01, P <0.01, respectively), and inactive duodenum The ulcer was also lower in the ulcer group than in the control group (P <0.01), but there was no difference between the inactive ulcers (P> 0.05). Conclusion The decrease of EGF may play a role in the pathogenesis of peptic ulcer.