采用正交设计的方法比较了龈沟液(GCF)中,乳酸脱氢酶(LDH)活性与牙龈指数(GI)和牙周袋深度(PD)间的关系,并比较了 GCF 中 LDH 的二种表达方式,即单位牙的 LDH 活性(LDH/牙)和单位GCF 的 LDH 活性(LDH/GCF)。结果显示,单位 GCF 的 LDH 活性不受 GCF 流量的影响,能较客观地反映其与临床指标间的关系。GCF 中 LDH 的活性随临床病变程度的加重有增加的趋势,而 LDH/GCF主要能够反映患病部位与相对正常部位炎症程度的差别。 The relationship between lactate dehydrogenase (LDH) activity and gingival index (GI) and periodontal pocket depth (PD) in GCF was compared using orthogonal design method. The expressions of LDH activity (LDH / tooth) and LDH activity (LDH / GCF) per unit tooth were measured. The results showed that unit LDF activity of GCF was not affected by GCF flow, which could objectively reflect its relationship with clinical indicators. The activity of LDH in GCF tends to increase with the degree of clinical lesion, and LDH / GCF mainly reflects the difference of inflammation degree between the diseased and normal parts.