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对134例DN患者在原糖尿病治疗的基础上,随机分为654-2治疗组74例和口服依那普利对照组60例,654-2采用剂量递增治疗,疗程均为2周,观察治疗前后患者尿白蛋白定量、血压、血脂、血糖、血液流变学的变化情况。结果:治疗组和对照组比较,尿白蛋白定量、全血低切黏度、全血低切黏度、血浆黏度均明显降低(P<0.01),血压、血脂、血糖无明显变化(P>0.05)。结论:654-2对早期糖尿病有较好的治疗作用。
On the basis of the treatment of primary diabetes, 134 patients with DN were randomly divided into two groups: 74 patients in the 654-2 group and 60 patients in the oral enalapril group, and 654-2 patients received dose escalation. The course of treatment was 2 weeks. Before and after treatment Urinary albumin in patients with quantitative, blood pressure, blood lipids, blood glucose, blood rheology changes. Results: Compared with the control group, urinary albumin, whole blood low shear viscosity, whole blood low shear viscosity and plasma viscosity were significantly decreased (P <0.01), and no significant changes in blood pressure, blood lipids and blood glucose (P> 0.05) . Conclusion: 654-2 has a good therapeutic effect on early diabetes.