论文部分内容阅读
目的:检测山东汉族梅毒患者与HLA-DRB1等位基因的相关性。方法:应用聚合酶链反应-序列特异性引物技术(PCR-SSP)对196例山东汉族梅毒患者与500例山东汉族正常对照的HLA-DRB1等位基因表现频率进行检测。结果:患者组DRB1*14等位基因的出现频率高于对照组(P<0.05);DRB1*16等位基因的出现频率与对照组无显著差异(P>0.05)。结论:HLA-DRB1*14等位基因可能是梅毒的易感基因。
Objective: To detect the association of HLA-DRB1 alleles with Shandong Han syphilis patients. Methods: PCR-SSP was used to detect the frequency of HLA-DRB1 alleles in 196 cases of Han ethnic syphilis in Shandong province and 500 normal Han controls in Shandong province. Results: The frequency of DRB1 * 14 allele in patients was higher than that in control group (P <0.05). The frequency of DRB1 * 16 allele was not significantly different from that in control group (P> 0.05). Conclusion: HLA-DRB1 * 14 allele may be a susceptible gene of syphilis.