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目的:探讨颅内转移瘤患者最适合的治疗方案,为改善颅内转移瘤患者生存质量及延长生存时间提供依据。方法:本组颅内转移瘤患者186例,根据患者病情及影像学资料分为Ⅰ组(手术+放疗+化疗组)81例、Ⅱ组(放疗+化疗组)66例、Ⅲ组(化疗组)14例、Ⅳ组(放疗组)14例及Ⅴ组(支持治疗组)11例。比较各组患者颅内高压、神经压迫症状治疗的有效率及平均生存期,对可随访到患者的近期和远期疗效进行统计学分析。结果:Ⅰ组患者颅内高压、神经压迫症状治疗的有效率及平均生存期分别较Ⅱ、Ⅲ及Ⅴ组明显提高,差异均有统计学意义(P<0.05),而Ⅰ组与Ⅳ组组间比较差异无统计学意义(P>0.05)。结论:颅内转移瘤患者要采用个体化治疗方案,对一般状况较好的患者,首选为手术联合放疗和化疗,其次为放疗。
Objective: To explore the most suitable treatment for patients with intracranial metastases, to provide evidence for improving the quality of life and prolonging the survival time of patients with intracranial metastases. Methods: 186 patients with intracranial metastases were divided into group Ⅰ (operation + radiotherapy + chemotherapy group), patients in group Ⅱ (radiotherapy + chemotherapy group), group Ⅲ (chemotherapy group ) In 14 cases, group Ⅳ (radiotherapy group) in 14 cases and group V (supportive treatment group) in 11 cases. Compare the effective rate and mean survival time of intracranial hypertension and nerve compression symptom treatment in each group, and make a statistical analysis on the short-term and long-term effects that can be followed up to patients. Results: The effective rate and mean survival time of patients with intracranial hypertension and neurological symptoms in group Ⅰ were significantly higher than those in groups Ⅱ, Ⅲ and Ⅴ (P <0.05), while those in group Ⅰ and Ⅳ There was no significant difference between the two groups (P> 0.05). Conclusion: Patients with intracranial metastases should adopt individualized treatment plan. For patients with better general conditions, the first choice is operation combined with radiotherapy and chemotherapy, followed by radiotherapy.