【摘 要】
：
To investigate the treatment effect of 2-selenium bridged β-cyclodextrin(2-SeCD), a GPX mimic, on the stroke of stroke-prone spontaneously hypertensive rats(SH
【机 构】
：
Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education,Jilin Institute
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To investigate the treatment effect of 2-selenium bridged β-cyclodextrin(2-SeCD), a GPX mimic, on the stroke of stroke-prone spontaneously hypertensive rats(SHRSP), fifty-two SHRSP of 8-week old were randomly divided into four groups A, B, C and control group D. The rats of groups A, B, C and D were given 1.0%-1.5% NaCl mass fraction as drinking fluid. After onset of stroke, groups A, B and C were given orally 16.05, 160.5 and 1605 mg*kg-1*day-1 of 2-SeCD, respectively, and group D was given water for 2 weeks. The clinical score of stroke, systolic blood pressure(SBP), survival time of rats were recorded and the histopathologic examinations of their brain and carotid artery were made after decapitation. The clinical scores of stroke after treatment with 160.5 mg*kg-1*day-1(Group B) and 1605 mg*kg-1*day-1(Group C) of 2-SeCD are 2.55±0.98 and 1.98±0.79, respectively, those are obviously lower than that of group D(3.41±0.83, p
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