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目的:通过临床应用CYNERGY脉冲染料激光与平阳霉素局部注射治疗小儿眼睑血管瘤,观察对比两者的疗效和不良反应。方法:收集2008-2010年在广州市妇女儿童医疗中心治疗的眼睑草莓状血管瘤患儿70例,混合型血管瘤患儿92例,两种类型血管瘤分别分组进行平阳霉素注射及激光治疗,随诊1～2年,对比其疗效及不良反应。结果:眼睑草莓状血管瘤患儿平阳霉素组及激光治疗组两组疗效比较,前者总有效率为93.9%,后者总有效率为97.3%,两者差异无统计意义(P>0.01)。眼睑混合型血管瘤惠儿平阳霉素组及激光治疗组两组疗效比较,前者总有效率为98.0%,后者总有效率为86.1%,两者差异有统计学意义(P<0.01)。激光治疗组的不良反应明显比平阳霉素组小,两者差异有统计学意义(x~2=9.370,P<0.05)。结论:针对病变较表浅的草莓状毛细血管瘤,激光及平阳霉素治疗两种方法均有显著效果。且激光治疗治愈率高,不良反应小。针对病变较深的混合型毛细血管瘤,平阳霉素注射治疗效果优于激光治疗效果。是目前理想治疗小儿混合型毛细血管瘤的方法之一。
OBJECTIVE: To observe the curative effect and adverse reactions of pediatric eyelid hemangioma by using CYNERGY pulsed dye laser and pingyangmycin injection locally. Methods: Seventy patients with strawberry eyelid hemangiomas and 92 patients with mixed hemangiomas were treated in Guangzhou Women and Children’s Medical Center during 2008-2010. The two types of hemangiomas were treated with pingyangmycin injection and laser treatment respectively , Followed up for 1 to 2 years, compared with its efficacy and adverse reactions. Results: There was no significant difference between the two groups (P> 0.01). The total effective rate of the former was 93.9% in the bleomycin group and the laser treatment group, and the latter was 97.3% . Eyelid mixed hemangioma benefit children Pingyangmycin group and laser treatment group compared the two groups, the former total effective rate was 98.0%, the latter total effective rate was 86.1%, the difference was statistically significant (P <0.01). Adverse reactions in the laser treatment group were significantly smaller than those in the pingyangmycin group, and the difference was statistically significant (x ~ 2 = 9.370, P <0.05). Conclusion: For the lesions of superficial strawberry capillary hemangioma, laser and pingyangmycin both methods have a significant effect. And laser treatment of high cure rate, adverse reactions. For lesions of deep mixed capillary hemangioma, pingyangmycin injection treatment is better than laser treatment effect. Is the ideal treatment of children with mixed capillary hemangioma one of the ways.